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Methadone is a long-acting synthetic opioid medication used primarily in the treatment of opioid use disorder (OUD) and for chronic severe pain when other treatments are ineffective. It works by binding to opioid receptors in the brain, reducing cravings and withdrawal symptoms while producing a more stable, controlled effect than short-acting opioids. Because of its potency and long half-life, methadone must be prescribed and monitored by licensed healthcare professionals.

Medical Uses

• Opioid use disorder treatment: Helps individuals stabilize, reduce illicit opioid use, and support long-term recovery.

• Pain management: Prescribed for chronic pain when alternatives are insufficient.

• Maintenance therapy: Used under clinical supervision within certified treatment programs.

Dosage Information (Educational Only)

Methadone dosing must always be determined by a licensed clinician, as the wrong dose can lead to overdose, respiratory depression, or death. Typical ranges include:

• Initial dose: Commonly between 10–30 mg on the first day, depending on tolerance and opioid dependence history.

• Titration: Increased gradually in small increments (e.g., 5–10 mg every few days) under medical supervision.

• Maintenance dose: Often ranges from 60–120 mg per day, but varies by individual response and clinical judgment.

For Chronic Pain

• Starting dose: Usually 2.5–10 mg every 8–12 hours, adjusted cautiously.

• Methadone accumulates in the body, so dose adjustments must be slow and carefully monitored.

Never adjust or take methadone without medical oversight. Combining it with alcohol, benzodiazepines, or other sedatives significantly increases risk.

Key Safety Points

• Methadone should only be obtained legally through a licensed pharmacy or opioid treatment program.

• Abruptly stopping methadone can cause severe withdrawal; tapering must be medically supervised.

• Regular ECG monitoring may be recommended, as methadone can affect heart rhythm.

• Misuse, sharing, or buying unregulated methadone online is extremely dangerous due to risks of contamination, incorrect dosage, and legal consequences.